FDG Overview


MUAE FDG (18F) I.V injectable solution

Fluorine-18, with 109.8 min half-life is produced via 18O (p,n) 18F reaction by proton irradiation of H2 18O target in a cyclotron. 2-18F-Fluoro-2-deoxy-D-glycose (18FDG) is a ready to use radiopharmaceutical to I.V injection as sterile, pyrogen free, colourless solution or light yellow coloured solution produced in the automatic synthesis unit via SN2 nucleophilic substitution method

What is MUAE FDG (18F) I.V injectable solution?

FDG (fluorodeoxyglucose) is an injectable radiopharmaceutical drug used for human diagnosis utilizing the Positron Emission Tomography scanner. FDG production is a pharmaceutical aseptic process involving radioactive material. In addition to the complex chemical process, special attention has to be paid with respect to the pharmaceutical requirements and the radiation protection rules & regulations. This implies a lot of constrains not only on the process itself but also on the production facility design (radiation safety, HVAC (heating-ventilating and air conditioning), building monitoring system, etc.). Moreover, appropriately qualified and trained personnel are needed.

How does MUAE FDG (18F) I.V injectable solution Act?

After IV injection to the patient, it is metabolized in the body in a way similar to Glucose and accumulates in the cells which consume Glucose as the primary energy source. Tumours are known to aggressively consume Glucose more than surrounding tissues. This differentiation in metabolism makes imaging and diagnosing tumours possible. MUAE FDG (18F) injectable solution is completely eliminated from the body within 3 to 24 hours, and it may be used in imaging heart for myocardium analysis, as well as brain in addition to its wide use in oncology.